By Francois Terrier
This publication offers a finished review of nucleophilic fragrant substitutions, concentrating on the mechanistic and artificial positive factors that govern those reactions.
The first bankruptcy provides a close mechanistic research of the criteria identifying the feasibility of SNAr substitutions, delivering decisive details to foretell regioselectivity of many reactions and to outline the stipulations for concerted SNAr tactics. Reflecting the main function performed via those species as intermediates in such a lot SNAr reactions, bankruptcy 2 then discusses the chemistry of anionic sigma-complexes. bankruptcy three describes the concept that of superelectrophilicity in SNAr substitutions, because it has lately emerged from the reactivity of strongly electron-deficient fragrant and heteroaromatic constructions. the various man made purposes are thought of intensive within the chapters four and five that keep on with on intermolecular and intramolecular nucleophilic fragrant substitutions. Then, bankruptcy 6 makes a speciality of substitutions continuing officially via displacement of a hydride ion, a scorching subject within the box. the ultimate bankruptcy brings jointly concise but accomplished discussions surrounding SNAr photosubstitutions, radical substitutions, and ANRORC substitutions.
Authored via a hugely revered chemist who has contributed tremendously to the sector during the last twenty years, it is a useful details resource for all natural chemists operating in academia or the pharmaceutical and agrochemical industries.
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Modern Nucleophilic Aromatic Substitution by Francois Terrier