Pierfausto Seneci's Molecular Targets in Protein Misfolding and PDF

By Pierfausto Seneci

ISBN-10: 0128001860

ISBN-13: 9780128001868

ISBN-10: 0128103183

ISBN-13: 9780128103180

Aimed at "drug discoverers" – i.e. any scientist who's drawn to neurodegenerative illnesses in most cases, and find disease-modifying remedies specifically – the 1st variation of Molecular goals in Protein Misfolding and Neurodegenerative Disease will include either a close, discipline-specific insurance (paragraphs on medicinal chemistry, on scientific and preclinical characterization of compounds in improvement, on track id and validation, on genetic elements influencing a pathology, etc.) and a drug discovery-oriented, total evaluate of every aim (validation, druggability, latest leads, etc.). jointly those will fulfill the wishes of assorted audiences, together with in vitro biologists, pharmacologists, medicinal chemists, etc.

  • Written to supply a finished assurance of disease-modifying mechanisms and compounds opposed to neurodegenerative diseases
  • Provides a “drug discovery” software orientated viewpoint, comparing objectives and applicants for his or her total healing potential
  • Provides discipline-specific chapters (medicinal chemistry, goal validation, preclinical and medical development
  • Provides an outline on a few molecular mechanisms (e.g. phosphorylation, chaperon refolding, ubiquitination, autophagy, microtubule transportation, protease cleavage, etc.) with relevance for any disorder area
  • Contains a extra thorough description of the healing relevance of ~10 particular molecular targets

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Molecular Targets in Protein Misfolding and Neurodegenerative Disease by Pierfausto Seneci

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