Read e-book online The Epothilones: An Outstanding Family of Anti-Tumor Agents: PDF

By Johann H. Mulzer,Karl-Heinz Altmann,Gerhard Höfle,Rolf Müller,Kathrin Prantz

ISBN-10: 3211782060

ISBN-13: 9783211782064

ISBN-10: 3211999280

ISBN-13: 9783211999288

Epothilones have obtained strange cognizance over the last ten years. they're novel antitumor medicines which greatly like their predecessor paclitaxel (Taxol) act through microtubule stabilization. compared to paclitaxel and a few replacement medicinal drugs with the same mode of bioaction (e.g. laulimalide, eleutherobin, peluroside, discodermolide) the epothilones have major benefits, certainly very excessive task within the nanomolar variety and coffee susceptibility in the direction of multidrug resistance. Epothilone B and a number of other derivatives thereof are in part I-III scientific trials; considered one of them (ixabepilone, BMS) is already out there, others are meant to look out there within the close to destiny. All clearly taking place epothilones were remoted from Sorangium cellulosum; their antitumor motion is traced again to the stabilization of microtubules. consequently, the formation of the mitototic spindle is illegal and the telephone undergoes apoptosis.

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The Epothilones: An Outstanding Family of Anti-Tumor Agents: From Soil to the Clinic: 90 (Fortschritte der Chemie organischer Naturstoffe Progress in the Chemistry of Organic Natural Products) by Johann H. Mulzer,Karl-Heinz Altmann,Gerhard Höfle,Rolf Müller,Kathrin Prantz


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