Jos Kleinjans's Toxicogenomics-Based Cellular Models: Alternatives to Animal PDF

By Jos Kleinjans

ISBN-10: 0123978629

ISBN-13: 9780123978622

Toxicogenomics-Based mobile Models is a distinct and important reference for all educational researchers making use of toxicogenomic equipment with admire to animal trying out for chemical safeguard. This source deals state of the art details at the software of toxicogenomics to constructing choices to present animal toxicity checks. by way of illustrating the advance of toxicogenomics-based mobile types for serious endpoints of toxicity and offering real-world examples for validation and knowledge research, this ebook offers an evaluation of the present kingdom of the sphere, in addition to possibilities and demanding situations for the longer term. Written through well known foreign toxicological specialists, this e-book explores ‘omics expertise for constructing new assays for toxicity trying out and protection evaluate and offers the reader with a targeted exam of other capacity to animal testing.

  • Describes the state of the art in constructing toxicogenomics-based mobile types for chemical-induced carcinogenicity, immunotoxicity, developmental toxicity, neurotoxicity and replica toxicity
  • Illustrates find out how to validate toxicogenomics-based substitute attempt versions and offers an outlook to societal and fiscal implementation of those novel assays
  • Includes an summary of present checking out tools and probability overview frameworks
  • Provides a real-world evaluate through articulating the present improvement and demanding situations in toxicogenomics whereas suggesting how you can circulation this box forward

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Toxicogenomics-Based Cellular Models: Alternatives to Animal Testing for Safety Assessment by Jos Kleinjans

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