By Ramesh C. Gupta
This text/reference booklet presents the main entire insurance of anticholinesterase compounds (Organophosphates and Carbamates), which represent the biggest variety of chemical compounds which are basically used as pesticides in agriculture, undefined, and round the home/garden. a few OPs (nerve brokers) were utilized in chemical conflict and terrorist assaults, whereas a few OPs and CMs were instructed as healing brokers in human medication in addition to in veterinary medication. Many chemical substances of either periods are tremendous poisonous and absence selectivity, hence their inadvertent/accidental use keeps to pose a chance to human and animal future health, aquatic platforms and natural world. those anticholinesterase brokers produce quite a few toxicological results in objective and nontarget organs.
In mild of this complexicity, this multi-authored ebook is written by way of the well-known scientists from many nations. The e-book is geared up into 9 sections, with a complete of forty nine chapters, to supply in-depth wisdom on a variety of facets of OP and CM compounds, together with their use, category, mechanism-based toxicity, and prophylactic and healing measurements. a number of chapters are written with certain emphasis to hide well timed subject matters, comparable to chemical struggle brokers, physiologically-based pharmacokinetic modeling, constitution and serve as of cholinesterases, paraoxonase, carboxylesterases; developmental neurotoxicity, the intermediate syndrome, oxidative pressure, endocrine disruption, and DNA damage/gene expression and carcinogenesis. Section-VI with five chapters is particularly dedicated to hazard review, and protection and regulatory guidance for pesticides.
- Describes every little thing you want to find out about Organophosphates and Carbamates
- Extensively covers insecticides, nerve brokers, healing medicines, and flame retardants
- Describes epidemiology of the world's significant mess ups related to Organophosphates and Carbamates
- Covers animal, human, aquatic, and flora and fauna toxicity of Anticholinesterases
- Insights into in-depth cholinergic and noncholinergic mechanisms of toxicity
- Describes fresh developments in cholinesterases, paraoxonases, carboxylesterases, oxidative rigidity, endocrine disruption, cardiac and pulmonary toxicity, and carcinogenesis
- Provides in vitro and in vivo versions for neurotoxicity testing
- Integrates wisdom of reviews in lab animals and humans
- Offers risk/safety evaluation and national/international directions for permissible degrees of pesticide residues
- Describes administration of Anticholinesterase poisoning in humans
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Toxicology of Organophosphate & Carbamate Compounds by Ramesh C. Gupta